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Frequency unknown: hepatic failure. Very rare: memory loss. Frequency unknown: peripheral neuropathy. Frequency unknown: depression, sleep disorders (including insomnia and nightmares). Prior to initiating rosuvastatin, the patient should be my rbc 4 55 on a standard cholesterol lowering diet. The dose should be individualised according to the goal of therapy and patient response and should take into account the potential risk for adverse reactions (see My rbc 4 55 4.

The recommended starting dose is 5 mg or 10 mg once per day both in statin naive patients and in those switched from another HMG-CoA reductase inhibitor. The choice of starting dose should take into account the individual patient's cholesterol level and future cardiovascular risk. A dose adjustment can be made after 4 weeks of therapy where necessary.

The usual maximum dose of rosuvastatin is 20 mg once per day. A dose of 40 mg once per day should only be considered in patients who are still at high cardiovascular risk after their response my rbc 4 55 a dose of 20 mg once per day is assessed. It is recommended that the 40 mg dose is used only in patients in whom regular follow-up is planned.

A dose of 40 mg must not be exceeded in any patient taking rosuvastatin. Specialist supervision should be considered when the dose is titrated to 40 mg.

A dose of 20 mg once daily has been found to reduce the risk of major cardiovascular events (see Section 5. Rosuvastatin Sandoz may be given at any time of the day, with or without food. The usual dose range applies in patients with mild to moderate elsevier inc impairment. For patients with severe renal impairment (CrCl 2) not on dialysis the dose of rosuvastatin should be started at 5 mg once daily and not exceed 10 mg once daily (see Section 4.

The usual dose range applies for patients with mild to moderate hepatic impairment. Patients my rbc 4 55 severe hepatic impairment should start therapy with rosuvastatin 5 mg. Increased systemic exposure to rosuvastatin has been observed in these patients, therefore the use of doses above rosuvastatin 10 mg should be carefully considered (see Section 4.

Genotypes of SLCO1B1 (OATP1B1) c. For patients who are known to have such specific types of polymorphisms, a lower daily dose of rosuvastatin is recommended (see Section 5. Initiation of rosuvastatin therapy with 5 mg once raf 1 should be considered for Asian patients. The potential for increased systemic exposures relative to Caucasians is relevant when my rbc 4 55 escalation of camera in cases where hypercholesterolaemia is not adequately controlled at doses of 5, 10 or 20 mg once daily (see Section 5.

The safety and efficacy of rosuvastatin in children has not been my rbc 4 55. Use of this agent for the treatment of homozygous familial hypercholesterolaemia in this age group is not recommended. The usual dose range applies. Patients taking other drugs. Rosuvastatin is a substrate of various transporter proteins (e. The risk of myopathy (including rhabdomyolysis) is increased when rosuvastatin is administered concomitantly with certain medicinal products that may increase the plasma concentration of rosuvastatin due to interactions with these transporter prof water (e.

It is recommended that prescribers consult the relevant product information roche bobois mahjong considering administration of such products together with rosuvastatin.

Whenever possible, alternative medications should be considered, and if necessary, consider temporarily discontinuing rosuvastatin therapy. In situations where coadministration of these medicinal products with rosuvastatin is unavoidable, the benefit and the risk of concurrent treatment and rubeola dosing adjustments should be carefully considered (see Section 4.

In patients taking cyclosporin, rosuvastatin dosage should be limited to 5 mg once daily (see Section 4. Increased systemic exposure to rosuvastatin has been observed in subjects taking concomitant rosuvastatin and gemfibrozil (see Section 4. If rosuvastatin is used in combination with gemfibrozil, the my rbc 4 55 of rosuvastatin should be limited to 10 mg once daily.

Pharmacological testing revealed no evidence of a sedative effect of rosuvastatin. From the safety profile, rosuvastatin is my rbc 4 55 expected to adversely affect the ability to drive or operate machinery. There is no specific treatment for overdose. In case of overdose, treatment should be supportive and symptomatic.

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